Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?

Autor: Julien Fromonot, Giovanna Mottola, Marion Marlinge, Jean Ruf, Franck Paganelli, Régis Guieu, Pierre Deharo
Přispěvatelé: Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Lucas, Nelly
Rok vydání: 2021
Předmět:
Deharo
0301 basic medicine
Homocysteine
hydrogen sulfide
Review
030204 cardiovascular system & hematology
M
lcsh:Chemistry
chemistry.chemical_compound
0302 clinical medicine
cardiovascular disease
J. Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing adenosine
Myocardial infarction
hyperhomocysteinemia
lcsh:QH301-705.5
Stroke
Spectroscopy
P
adenosine A(2A) receptors
General Medicine
Mottola
Guieu
3. Good health
Computer Science Applications
Fromonot
Cardiovascular Diseases
adenosine
Cardiology
medicine.symptom
medicine.medical_specialty
Hyperhomocysteinemia
Receptor
Adenosine A2A
Ischemia
Inflammation
Adenosinergic
Catalysis
Inorganic Chemistry
03 medical and health sciences
Paganelli
G
Internal medicine
[SDV.BBM] Life Sciences [q-bio]/Biochemistry
Molecular Biology
medicine
Animals
Humans
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
cardiovascular diseases
Physical and Theoretical Chemistry
Risk factor
Molecular Biology
Ruf
R
business.industry
Organic Chemistry
adenosine A2A receptors
J
Marlinge
equipment and supplies
medicine.disease
adenosine A 2A receptors
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
chemistry
F
business
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2021, 22 (4), pp.1690. ⟨10.3390/ijms22041690⟩
International Journal of Molecular Sciences, 2021, 22 (4), pp.1690. ⟨10.3390/ijms22041690⟩
International Journal of Molecular Sciences, Vol 22, Iss 1690, p 1690 (2021)
ISSN: 1422-0067
1661-6596
DOI: 10.3390/ijms22041690
Popis: The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent risk factor for CVD, stroke and myocardial infarction. However, homocysteine (HCy)-lowering therapy does not affect the inflammatory state of CVD patients, and it has little influence on cardiovascular risk. The HCy degradation product hydrogen sulfide (H2S) is a cardioprotector. Previous research proposed a positive role of H2S in the cardiovascular system, and we discuss some recent data suggesting that HHCy worsens CVD by increasing the production of H2S, which decreases the expression of adenosine A2A receptors on the surface of immune and cardiovascular cells to cause inflammation and ischemia, respectively.
Databáze: OpenAIRE
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