Allergic Reactions to E. coli L-Asparaginase Do Not Affect Outcome in Childhood B-precursor Acute Lymphoblastic Leukemia
| Autor: | Pierre Wacker, Jeanette Pullen, Jonathan J. Shuster, Michael E. Harris, Vita J. Land, Joanne Kurtzberg, Bruce M. Camitta |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Allergy medicine.medical_specialty Adolescent Lymphoblastic Leukemia Erwinia medicine.disease_cause Gastroenterology law.invention L asparaginase Bacterial Proteins Randomized controlled trial law Asparaginase/adverse effects/immunology/therapeutic use Internal medicine Escherichia coli Hypersensitivity medicine Asparaginase Humans Escherichia coli/enzymology Child ddc:618 biology Group study business.industry Infant Hematology biology.organism_classification medicine.disease Burkitt Lymphoma Bacterial Proteins/adverse effects/immunology/therapeutic use Regimen Treatment Outcome Oncology Child Preschool Pediatrics Perinatology and Child Health Immunology Erwinia/enzymology business Burkitt Lymphoma/drug therapy Hypersensitivity/immunology |
| Zdroj: | Journal of Pediatric Hematology / Oncology, Vol. 29, No 9 (2007) pp. 627-32 |
| ISSN: | 1077-4114 |
| DOI: | 10.1097/mph.0b013e3181483df1 |
| Popis: | We describe the outcome of children with B-precursor acute lymphoblastic leukemia registered on Pediatric Oncology Group 8602 who switched to Erwinia asparaginase (ASP) due to an allergy to the Escherichia coli product. Between February 1986 and January 1991, children in complete remission after induction that included intramuscular E. coli ASP (6000 U/m2x6) were randomized for consolidation. One regimen included intensive weekly intramuscular E. coli ASP (25,000 U/m2/wkx24). In case of an allergic reaction to E. coli ASP, Erwinia ASP was substituted at the same dose and schedule. Of the 540 eligible patients, 408 switched to Erwinia ASP due to an allergic reaction. Allergic reactions were significantly associated with younger age, white race, and standard-risk acute lymphoblastic leukemia. Multivariate Cox analysis adjusting for these factors demonstrated no correlation between the switch per se or the timing of the switch and event-free survival. |
| Databáze: | OpenAIRE |
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