Association between ICAM-1 level and diabetic retinopathy: a review and meta-analysis
| Autor: | Jing Ya Zhai, Rong Li, Yang Yao, Lihui Long, Lei Zhao, Junhui Du, Na Luo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Diabetic Retinopathy business.industry Subgroup analysis General Medicine Publication bias Diabetic retinopathy Disease medicine.disease Intercellular Adhesion Molecule-1 Prognosis 03 medical and health sciences 0302 clinical medicine Sample size determination 030220 oncology & carcinogenesis Internal medicine Diabetes mellitus Meta-analysis 030221 ophthalmology & optometry medicine Disease Progression Humans business Pathological Biomarkers |
| Zdroj: | Postgraduate medical journal. 95(1121) |
| ISSN: | 1469-0756 |
| Popis: | Elevated levels of proinflammatory markers are evident in patients with diabetic retinopathy (DR) and are associated with disease progression and prognosis. Intercellular adhesion molecule-1 (ICAM-1) is involved in inflammation and acts as a local intensifying signal in the pathological processes associated with chronic eye inflammation. The aim of this systematic review and meta-analysis was to investigate the relationship between ICAM-1 level and DR. Online electronic databases were searched to retrieve all relevant articles published before December 2017. The standard mean difference (SMD) and their 95% CI were included and then pooled with a random effects model. Subgroup analysis and metaregression analysis were applied to explore the sources of heterogeneity, and publication bias was calculated to assess the quality of pooled studies. A total of 11 articles, containing 428 patients with DR and 789 healthy controls, were included in this meta-analysis. The results indicated a significant increase in ICAM-1 level in the DR group compared with the control group (SMD: 1.20, 95%CI 0.83 to 1.57, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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