Long-term cardiovascular risk and costs for myocardial infarction survivors in a US commercially insured population
| Autor: | David M. Kern, Ozgur Tunceli, Mogens Westergaard, Bingcao Wu, Niklas Hammar, Phillip Hunt, Carl Mellström |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Databases Factual Population Myocardial Infarction Kaplan-Meier Estimate Disease Type 2 diabetes 030204 cardiovascular system & hematology Disease-Free Survival Coronary artery disease 03 medical and health sciences 0302 clinical medicine Risk Factors Cause of Death Internal medicine Secondary Prevention medicine Humans Survivors 030212 general & internal medicine Myocardial infarction education Stroke Aged Proportional Hazards Models Cause of death education.field_of_study Insurance Health business.industry Proportional hazards model Health Care Costs General Medicine Middle Aged medicine.disease United States Surgery Treatment Outcome Diabetes Mellitus Type 2 Cardiovascular Diseases Kidney Failure Chronic Female business |
| DOI: | 10.6084/m9.figshare.6715301.v1 |
| Popis: | Objective To quantify clinical and cost long-term outcomes in cardiovascular stable post-myocardial-infarction patients. Research design and methods Subjects with a history of myocardial infarction (MI) who were 50–64 years old and MI- and stroke-free for ≥12 months (index date) were identified in a large US claims database. Individuals were followed for up to 5 years (mean: 2.0 years) after their index date. Main outcome measures Rates of MI, stroke, all-cause death, and a composite of these were analyzed via Cox regression models, adjusted for covariates. Results are reported for the overall population and the subgroups of those with type 2 diabetes, additional prior MI, and non-end-stage renal disease. As a secondary endpoint healthcare costs were evaluated at baseline and during each year of follow-up. Results Over the follow-up period, which averaged 2 years, 7.6% of all 13,492 subjects (10.5% vs. 5.4% with and without the selected risk factors, respectively) experienced at least one of the outcome events. The cumulative incidence rates over the entire follow-up period for the primary composite outcome were 20.8% and 12.2% for those with and without the selected atherothrombotic risk factors, respectively. The cardiovascular-related per-person-per-year healthcare costs during follow-up were higher in those with ≥1 additional risk factor compared to those without: $15,247 versus $7521. Costs were elevated over baseline costs throughout follow-up. Limitations Administrative claims data lack clinical detail. Generalizability of results is limited to the US commercially insured population of a similar age to that included in this study. Conclusions High risk MI survivors who have been event free for ≥1 year remained at substantial risk of CV events and had increased healthcare costs for up to 5 years post-MI. These long-term risks have not been previously demonstrated in a working-age US population and suggest an unmet need for continuing secondary prevention long-term post-MI. |
| Databáze: | OpenAIRE |
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