An Innovative Wax-based Enteric Coating for Pharmaceutical and Nutraceutical Oral Products
| Autor: | Julie Tzu-Wen Wang, Marton Bohus, Rober Habashy, Mohamed Albed Alhnan, Beatriz C. Pereira, Mouhamad Khoder, Abdullah Isreb, Sitong Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
pharmacy
Alginates Pharmaceutical Science 02 engineering and technology Ceresin engineering.material 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Coating Theophylline medicine Wax Chromatography Cetyl palmitate B230 021001 nanoscience & nanotechnology Enteric coating Drug Liberation chemistry Solubility visual_art Emulsion Dietary Supplements visual_art.visual_art_medium engineering Tablets Enteric-Coated Rice bran wax Carnauba wax 0210 nano-technology medicine.drug Tablets |
| ISSN: | 0378-5173 |
| Popis: | In this work, a novel enteric coating based on natural waxes and alginate was reported. Initially, theophylline tablets were coated with emulsified ceresin wax in heated aqueous alginate solution using a fluidised bed coating technology. A coating level of 10% proved sufficient to prevent tablets from uptalking gastric medium (< 5%) and produced a delayed release profile that complies to the pharmacopeial criteria of enteric coating release. Then, a wide range of emulsions based on other natural waxes (white beeswax, yellow beeswax, cetyl palmitate, carnauba wax or rice bran wax) yielded coatings with similar disintegration times and release profiles. Interestingly, the ceresin-based coating showed a superior performance at inhibiting acid uptake and enabling highly pH-responsive drug release in comparison to different commercially available GRAS enteric coating products (Eudraguard® Control, Swanlac® ASL10, and Aquateric™ N100). The coating was stable for 6 months at 30°C and 65% RH. This innovative approach of applying hot O/W emulsion of natural waxes yielded an aesthetically attractive and stable coating with gastric protection and pH-sensitive release properties. The novel coating can be an efficient and promising alternative to overcome the shortcomings of current GRAS grade enteric coating products. [Abstract copyright: Copyright © 2020. Published by Elsevier B.V.] |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect