Evaluation of acute and subchronic toxicity of a non-anticoagulant, but antithrombotic algal heterofucan from the Spatoglossum schröederi in Wistar rats
| Autor: | Jailma Almeida-Lima, Edda Lisboa Leite, Naisandra Bezerra da Silva, Leandro Silva Costa, Hugo Alexandre Oliveira Rocha, Carlos Eduardo Bezerra de Moura, Diego Araujo Sabry, Maria de Lourdes Freitas, Nednaldo Dantas-Santos, Telma Maria Araújo Moura Lemos, Dayanne Lopes Gomes, Sara Lima Cordeiro |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
sulfated polysaccharide
medicine.drug_class Fucoidan Anticoagulant lcsh:RS1-441 Pharmacology Biology biology.organism_classification In vitro lcsh:Pharmacy and materia medica chemistry.chemical_compound chemistry fucoidan In vivo Toxicity Antithrombotic medicine Dictyotaceae brown seaweed General Pharmacology Toxicology and Pharmaceutics Adverse effect toxicological assessment |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 21, Iss 4, Pp 674-679 (2011) Revista Brasileira de Farmacognosia, Volume: 21, Issue: 4, Pages: 674-679, Published: 10 JUN 2011 Revista Brasileira de Farmacognosia v.21 n.4 2011 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
| Popis: | Fucan is a term used to denominate a family of sulfated polysaccharides rich in L-fucose. The brown alga Spatoglossum schröederi, Dictyotaceae, synthesizes three heterofucans named A, B, and C. Fucan A is a non-anticoagulant heterofucan which possesses potent antithrombotic (in vivo) and antiproliferative (in vitro) activities. However, its toxicity in vivo has not been determined. The present study examined the acute and subchronic toxicity of the fucan A in Wistar rats after subcutaneous administration. After that, the animals were killed and examined. The results showed in the acute study that fucan A did not cause general adverse effects and mortality in the concentrations 0, 20, 100, 1000, and 2000 µg/g body weight per rat for seven days. Regarding the subchronic study, the data showed that the fucan A did not cause any change in hematological and biochemistry parameters, as well as in the morphology, and in the size of the rat's organs analyzed at a concentration of 20 µg/g body weight per rat during a 62-day period. In conclusion, this study indicates this heterofucan is a compound with potential pharmacological value that has no toxicity in vivo. |
| Databáze: | OpenAIRE |
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