Influence of cadmium on two-kidney Goldblatt hypertension in Dahl rats
Autor: | Martha Heine, Edward V. Ohanian, Junichi Iwai |
---|---|
Rok vydání: | 1978 |
Předmět: |
Male
medicine.medical_specialty Hypertension Renal CADMIUM TOXICITY chemistry.chemical_element Blood Pressure Biology Kidney General Biochemistry Genetics and Molecular Biology Two kidney Internal medicine medicine Goldblatt hypertension Animals Genetic variability Adverse effect Cadmium Kidney metabolism Rats Inbred Strains Rats Endocrinology Phenotype chemistry Liver Injections Intraperitoneal Biological variability |
Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 158(3) |
ISSN: | 0037-9727 |
Popis: | In Dahl hypertension-resistant (R) and hypertension-sensitive (S) lines of rats, an ip cadmium injection exacerbated two-kidney Goldblatt hypertension and mortality in S but not in R rats. Renal and hepatic cadmium concentrations of S rats were markedly higher than those of R rats. These observations imply that the genetic background critically affects the adverse effects of cadmium on two-kidney Goldblatt hypertension in Dahl rats. |
Databáze: | OpenAIRE |
Externí odkaz: |