BCG vaccination in patients with severe combined immunodeficiency: complications, risks, and vaccination policies
| Autor: | Renata Formankova, Nermeen Galal, Funda Erol Cipe, Tomohiro Morio, Francisco J. Espinosa-Rosales, Diana Liberatore, Nima Rezaei, Viviana Listello, Masafumi Yamada, Graham Davies, Gyan Joshi, Anna Shcherbina, Reem Elfeky, María I. Pereira, Vojtech Thon, Ryuta Nishikomori, Fabiola Scancetti Tavares, Oscar Porras, Jose Gonçalo Marques, Anete Sevciovic Grumach, I. Esteves, Liliana Bezrodnik, Shereen M. Reda, Yoshitoshi Ohtsuka, Danuta Kowalczyk, Luciana Cristina Matos Cunha, Jorge Pinto, Bénédicte Neven, José Luis Franco, Maria Marluce dos Santos Vilela, Beatriz Tavares Costa Carvalho, Salem Al-Tamemi, Zohreh Nademi, Tadashi Ariga, Pérsio Roxo, Leticia Hernandez-Nieto, Anna Szaflarska, M. Enriqueta Nuñez-Nuñez, Beatriz E. Marciano, Thomas A. Fleisher, Waleed Al-Herz, Alisan Yildiran, Sergio D. Rosenzweig, Yu-Lung Lau, Heike Toshio, Juliana Themudo Lessa Mazzucchelli, S. Kiliç, Chiung Yu Huang, Aydan Ikinciogullari, Carlos Torres-Lozano, Z. Allwood, Andrea C. Gómez Raccio, Mary Slatter, Sara Elva Espinosa-Padilla, Figen Dogu, Andrew R. Gennery, Julio Orellana |
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| Přispěvatelé: | OMÜ |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pediatrics medicine.medical_treatment Medicina Clínica Comorbidity Kaplan-Meier Estimate Hematopoietic stem cell transplantation vaccine purl.org/becyt/ford/3.2 [https] Prevalence Immunology and Allergy Medicine BCG Recombination-activating gene hematopoietic stem cell transplant education.field_of_study Primary immunodeficiency Mortality rate Vaccination Hematopoietic Stem Cell Transplantation severe combined immunodeficiency 3. Good health Child Preschool BCG Vaccine Female purl.org/becyt/ford/3 [https] Medicina Critica y de Emergencia medicine.symptom Risk medicine.medical_specialty immune reconstitution syndrome CIENCIAS MÉDICAS Y DE LA SALUD mycobacteria Immunology Population RECÉM-NASCIDO complex mixtures Asymptomatic Article IL-2 receptor g Humans education Retrospective Studies Severe combined immunodeficiency business.industry newborn screening Infant Newborn Infant medicine.disease Surgery Severe Combined Immunodeficiency business BCG vaccine |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Journal of Allergy and Clinical Immunology; Vol 133 CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| Popis: | Ikinciogullari, Aydan/0000-0003-1145-0843; Pinto, Jorge A/0000-0003-2987-3238; Dogu, Figen/0000-0002-7869-4941; FRANCO, JOSE/0000-0001-5664-6415; Nishikomori, Ryuta/0000-0002-9407-6158; Al-Tamemi, Salem/0000-0002-7232-2629; Nishikomori, Ryuta/0000-0002-9407-6158; Rezaei, Nima/0000-0002-3836-1827; Roxo-Junior, Persio/0000-0001-6318-4132; Grumach, Anete/0000-0002-9803-0309; Morio, Tomohiro/0000-0002-9259-1025 WOS: 000333531700025 PubMed: 24679470 Background: Severe combined immunodeficiency (SCID) is a syndrome characterized by profound T-cell deficiency. BCG vaccine is contraindicated in patients with SCID. Because most countries encourage BCG vaccination at birth, a high percentage of patients with SCID are vaccinated before their immune defect is detected. Objectives: We sought to describe the complications and risks associated with BCG vaccination in patients with SCID. Methods: An extensive standardized questionnaire evaluating complications, therapeutics, and outcomes regarding BCG vaccination in patients given a diagnosis of SCID was widely distributed. Summary statistics and association analysis was performed. Results: Data on 349 BCG-vaccinated patients with SCID from 28 centers in 17 countries were analyzed. Fifty-one percent of the patients had BCG-associated complications, 34% disseminated and 17% localized (a 33,000- and 400-fold increase, respectively, over the general population). Patients receiving early vaccination ( |
| Databáze: | OpenAIRE |
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