A meta-analysis-derived proposal for a clinical, ultrasonographic, and cytological scoring system to evaluate thyroid nodules: the 'CUT' score
| Autor: | Alfredo Pontecorvi, Salvatore Maria Corsello, Laura Castellino, Carlo Antonio Rota, Paolo Campanella, Alessandro Prete, Francesca Ianni |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Thyroid nodules
Adult Male medicine.medical_specialty Pathology Scoring system Adolescent Endocrinology Diabetes and Metabolism Thyroid Gland 030209 endocrinology & metabolism Malignancy Risk Assessment 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Meta-Analysis as Topic Cytology medicine Humans Thyroid Nodule Aged Ultrasonography Aged 80 and over Cut score business.industry Curve analysis Malignancy risk Thyroid neoplasms Thyroid nodule Settore MED/13 - ENDOCRINOLOGIA Middle Aged medicine.disease Research Design 030220 oncology & carcinogenesis Meta-analysis Female Radiology business Cancer risk Algorithms |
| Popis: | The purpose of this study is to develop a new cancer risk score for preoperative assessment of thyroid nodules (TN) trying to reduce unnecessary thyroidectomies. On the basis of a recent meta-analysis of published literature, we assigned a matching value to the clinical (C) and ultrasonographic (U) features of TN with increased malignancy risk (MR). The created "CUT" score derived from "C+U" score, (CU[1-10] ), along with the five-tiered "T" (T[1-5] ), represents the cytologic result of the fine-needle aspiration. The C+U score was prospectively applied to 683 consecutive patients with 705 TN and validated through a ROC curve analysis. The CUT score was correlated with the histopathological diagnoses of 110 surgically resected TN. Fifty-five histologically benign TN had a mean C+U score of 2.4 versus 5.7 of 55 malignant TN (p0.001). Three categories were identified: low risk for C+U score ≤2.5 (MR: 9 %), intermediate risk for C+U score ≥2.75 and ≤5 (MR: 38 %), and high risk for C+U score ≥5.25 (MR: 95 %). Sensitivity and specificity were, respectively, 95 and 60 % for a cut-off value2.5, and 69 and 96 % for5. The "CUT" score can be easily applied, aiding clinicians in the evaluation of TN, especially in cases with indeterminate or repeated non-diagnostic FNA. |
| Databáze: | OpenAIRE |
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