Childhood abuse, promoter methylation of leukocyte NR3C1 and the potential modifying effect of emotional support
| Autor: | Edward A. Ruiz-Narváez, Lynn Rosenberg, Alexandra E. Shields, Andrea A. Baccarelli, Bobak Seddighzadeh, Hyang-Min Byun, Lauren A. Wise, Yvette C. Cozier, Julie R. Palmer |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Cancer Research Adolescent Poison control Biology Suicide prevention Occupational safety and health 03 medical and health sciences Young Adult Receptors Glucocorticoid Injury prevention Genetics Leukocytes Humans Child Abuse Child Promoter Regions Genetic Aged Infant Newborn Human factors and ergonomics Infant Social Support DNA Methylation Middle Aged Health equity 030104 developmental biology Sexual abuse Child Preschool DNA methylation Female Stress Psychological Clinical psychology Research Article |
| Zdroj: | Epigenomics. 8(11) |
| ISSN: | 1750-192X |
| Popis: | Aim: To investigate childhood abuse victimization in relation to adult DNA methylation levels in a novel region of NR3C1, with emotional support as a possible modifier. Materials & methods: 295 participants from the Black Women's Health Study. Multivariable linear regression models were used to compute differences in mean percent methylation levels. Results: Women reporting childhood abuse victimization exhibited higher mean NR3C1 methylation levels than nonabused women, with a clear dose–response relationship. Childhood emotional support appeared to attenuate associations only among women with the highest levels of physical and sexual abuse. Conclusion: NR3C1 mean methylation was higher among women who reported childhood abuse. Further research is warranted to clarify whether or the extent to which childhood emotional support buffers the association. |
| Databáze: | OpenAIRE |
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