Role of PTH in the Renal Handling of Phosphate
| Autor: | Syed J. Khundmiri, Eleanor D. Lederer, Rebecca D. Murray |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
endocrine system lcsh:R5-920 Renal oligopeptide reabsorption Chemistry Reabsorption Parathyroid hormone General Medicine Apical membrane Renal protein reabsorption Endocrinology Internal medicine GPCR signaling Npt2a medicine Cotransporter lcsh:Medicine (General) Homeostasis hormones hormone substitutes and hormone antagonists renal proximal tubule Hormone phosphate PTH |
| Zdroj: | AIMS Medical Science, Vol 2, Iss 3, Pp 162-181 (2015) |
| ISSN: | 2375-1576 |
| Popis: | Parathyroid hormone (PTH) is one of the primary phosphaturic hormones in the body. The type IIa sodium-phosphate cotransporter (Npt2a) is expressed in the apical membrane of the renal proximal tubule and is responsible for the reabsorption of the majority of the filtered load of phosphate. PTH acutely induces phosphaturia through the rapid stimulation of endocytosis of Npt2a and its subsequent lysosomal degradation. This review focuses on the homeostatic mechanisms underlying serum phosphate, with particular focus on the regulation of the phosphate transporter Npt2a by PTH within the renal proximal tubule. Additionally, the proximal tubular PTH-stimulated signaling events as they relate to PTH-induced phosphaturia are also highlighted. Lastly, we discuss recent findings by our lab concerning novel regulatory mechanisms of PTH-mediated reductions in Npt2a expression. |
| Databáze: | OpenAIRE |
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