The role of retinal fluid location in atrophy and fibrosis evolution of patients with neovascular age‐related macular degeneration long‐term treated in real world
| Autor: | Alfredo García-Layana, Sergio Recalde, Félix Armadá, Ana M Gómez-Ramírez, Manuel Saenz-de-Viteri, Maria Hernandez, Valentina Bilbao-Malavé, Jorge González-Zamora, Juan Donate, Oscar Ruiz-Moreno, Patricia Fernandez-Robredo, Javier Araiz, Sara Llorente-González, Jesús Barrio-Barrio, María José Rodríguez-Cid, Francisco J. Ascaso |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Visual acuity Angiogenesis Inhibitors Macular Degeneration 03 medical and health sciences Basal (phylogenetics) chemistry.chemical_compound 0302 clinical medicine Atrophy Slow progression Fibrosis Age related Ophthalmology medicine Humans Prospective Studies Aged Retrospective Studies Aged 80 and over business.industry Subretinal Fluid Retinal General Medicine Macular degeneration medicine.disease chemistry Intravitreal Injections Disease Progression 030221 ophthalmology & optometry Female medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Acta Ophthalmologica. 100 |
| ISSN: | 1755-3768 1755-375X |
| DOI: | 10.1111/aos.14905 |
| Popis: | To assess the effect of clinical factors on the development and progression of atrophy and fibrosis in patients with neovascular age-related macular degeneration (nAMD) receiving long-term treatment in the real world.An ambispective 36-month multicentre study, involving 359 nAMD patients from 17 Spanish hospitals treated according to the Spanish Vitreoretinal Society guidelines, was designed. The influence of demographic and clinical factors, including the presence and location of retinal fluid, on best-corrected visual acuity (BCVA) and progression to atrophy and/or fibrosis were analysed.After 36 months of follow-up and an average of 13.8 anti-VEGF intravitreal injections, the average BCVA gain was +1.5 letters, and atrophy and/or fibrosis were present in 54.8% of nAMD patients (OR = 8.54, 95% CI = 5.85-12.47, compared to baseline). Atrophy was associated with basal intraretinal fluid (IRF) (OR = 1.87, 95% CI = 1.09-3.20), whereas basal subretinal fluid (SRF) was associated with a lower rate of atrophy (OR = 0.40, 95% CI = 0.23-0.71) and its progression (OR = 0.44, 95% CI = 0.26-0.75), leading to a slow progression rate (OR = 0.34, 95% CI = 0.14-0.83). Fibrosis development and progression were related to IRF at any visit (p 0.001). In contrast, 36-month SRF was related to a lower rate of fibrosis (OR = 0.49, 95% CI = 0.29-0.81) and its progression (OR = 0.50, 95% CI = 0.31-0.81).Atrophy and/or fibrosis were present in 1 of 2 nAMD patients treated for 3 years. Both, especially fibrosis, lead to vision loss. Subretinal fluid (SRF) was associated with good visual outcomes and lower rates of atrophy and fibrosis, whereas IRF yields worse visual results and a higher risk of atrophy and especially fibrosis in routine clinical practice. |
| Databáze: | OpenAIRE |
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