Allele loss of tumour suppressor genes on chromosome 17 in human testicular germ cell tumours

Autor:	Edith Olah, M vanderLooij, I Bodrogi, Mihály Bak, H. Eid
Rok vydání:	2011
Předmět:	Cancer Research medicine.medical_specialty endocrine system diseases Cancer Biology Cell cycle medicine.disease Molecular biology Molecular medicine Chromosome 17 (human) Loss of heterozygosity Oncology Molecular genetics Cancer research medicine Deletion mapping neoplasms Gene
Zdroj:	International journal of oncology. 9(5)
ISSN:	1019-6439
Popis:	The molecular genetics of testicular germ cell tumours (TGCT) are still largely unknown. We investigated 20 TGCT tumours for allelic losses (LOH) of tumour supressor genes BRCA1, TP53 and of THRA1 on chromosome 17. We observed an overall loss of 50% for the whole chromosome. Detailed deletion mapping revealed no losses for the BRCA1 gene, 42% LOH for THRA1 and 11% allelic loss for the region telomeric to BRCA1. We observed 11% LOH for TP53. Our results suggest that allelic losses of BRCA1 and TP53 genes do not play a pivotal role in TGCT but that dysfunction of THRA1 or tumour suppressor gene(s) in this region may have an impact in the development of this cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660fc83171b203be5c8600e0a618b353 https://pubmed.ncbi.nlm.nih.gov/21541616 Zobrazit plný text záznamu