Autologous stem cell transplant for multiple myeloma: Impact of melphalan dose on the transplant outcome

Autor: Lalit, Kumar, Ranjit Kumar, Sahoo, Sudhir, Kumar, Annie K, Baa, Ghazal, Tansir, Neha, Pathak, Prabhat S, Malik, Om Dutt, Sharma, Anisha, Mathew, Ankit, Jha, Ritu, Gupta, Atul, Sharma, Ahitagni, Biswas, Rakesh, Kumar, Sanjay, Thulkar, Soumyaranjan, Malik, Ashish, Dutt
Rok vydání: 2022
Předmět:
Zdroj: Leukemialymphoma.
ISSN: 1029-2403
Popis: We evaluated impact of melphalan dose on transplant outcomes for multiple myeloma. Between 1995 and 2019 459 consecutive patients received a transplant; 69(15%) received melphalan ≤150 mg/m2 (Mel 150 cohort) and 390 (85%) melphalan 200 mg/m2 (MEL 200 cohort). The primary outcome was overall survival (OS) from the date of transplant. Progression-free survival (PFS), engraftment, transplant response, and cumulative relapse at 2 years were secondary outcome measures. Patients in Mel 150 cohort had adverse clinical and laboratory parameters at base line. Transplant response was better for Mel 200 cohort (
Databáze: OpenAIRE