Multilayer amniotic membrane transplantation in the treatment of corneal perforations
| Autor: | Rosario Touriño, María Teresa Rodríguez-Ares, Maria J. López-Valladares, Francisco Gude |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Perforation (oil well) Cornea Medicine Humans Amnion Corneal Ulcer Ocular inflammation Aged Aged 80 and over Wound Healing Graft rejection Nylon sutures Biological Dressings Rupture Spontaneous business.industry Epithelium Corneal Corneal perforation Middle Aged medicine.disease eye diseases Surgery Transplantation Ophthalmology Female sense organs business Wound healing Bandage contact lens |
| Zdroj: | Cornea. 23(6) |
| ISSN: | 0277-3740 |
| Popis: | Purpose To determine if multilayer amniotic membrane transplantation (AMT) is useful in the treatment of corneal perforations, and in particular to assess to what extent efficacy is affected by perforation size. Methods Fifteen patients (15 eyes) with corneal perforations of different sizes were divided into 3 groups: group A (microperforation, 6 eyes), group B (0.5-1.5 mm, 4 eyes), and group C (>1.5 mm, 5 eyes). The corneal perforation was caused by autoimmunity-related ulcer (3 eyes), neurotrophic ulcer (9 eyes), infectious keratitis (1 eye), or postkeratoplasty ulcer (2 eyes). Two layers of AM (for microperforations) or 3-4 layers (for the other groups) were trimmed to the size of the ulcer and sutured in place with interrupted 10-0 nylon sutures. In all cases, a bandage contact lens was then applied. Results Mean epithelialization time was 3.7 weeks (range 2-6). Mean time to recovery of corneal stroma thickness was 10.1 weeks (range 7-15). In all cases, ocular inflammation subsided within 2-5 weeks. The treatment was judged successful in 73% (11/15) of eyes. Three of the 4 unsuccessful treatments were of perforations 3 mm or more in diameter; of the 5 eyes with perforations of more than 1.5 mm in diameter, only 2 were treated successfully. Conclusions These results suggest that multilayer AMT is effective for treating corneal perforations with diameter less than 1.5 mm. The technique may be a good alternative to penetrating keratoplasty, especially in acute cases in which graft rejection risk is high. |
| Databáze: | OpenAIRE |
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