Emerging treatment options for short bowel syndrome: potential role of teduglutide
| Autor: | null Tee, null Gabe, Katharina Wallis |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
endocrine system
business.industry digestive oral and skin physiology Gastroenterology Treatment options 1103 Clinical Sciences parenteral nutrition Review intestinal adaptation Bioinformatics Glucagon-like peptide-2 Short bowel syndrome medicine.disease Teduglutide Inflammatory bowel disease Intestinal absorption chemistry.chemical_compound glucagon-like peptide-2 Parenteral nutrition chemistry intestinal failure Medicine In patient business |
| Zdroj: | Clinical and Experimental Gastroenterology |
| ISSN: | 1178-7023 |
| Popis: | Introduction Current medical management of short bowel syndrome (SBS) involves the use of lifelong parenteral nutrition (PN). Glucagon-like peptide-2 (GLP-2), an important intestinotrophic growth factor has been shown to increase intestinal absorption in SBS through augmentation of post-resection intestinal adaptation. This may lead to the reduction of PN dependence in patients with SBS. Areas covered in review Advancing research of GLP-2 physiology has spurred the growing understanding of the diverse effects of GLP-2. The development of the degradation resistant GLP-2 analog, teduglutide (Gattex(TM), NPS Pharmaceuticals, Bedminster, NJ), has allowed its exploration as a therapeutic agent in a variety of clinical settings. Recent multicenter, placebo-controlled studies of GLP-2 in SBS patients demonstrate meaningful reductions in PN requirements with good safety profiles. The reparative and immunomodulatory effects of teduglutide may also be beneficial in patients with inflammatory bowel disease (IBD). Safety concerns about possible carcinogenic properties during long-term use require ongoing evaluation. Summary GLP-2 appears to offer a novel adjuvant treatment modality for SBS. Promise for its use in other clinical settings like IBD has been shown in small pilot studies. |
| Databáze: | OpenAIRE |
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