The healing of colonic anastomoses after early intraperitoneal chemotherapy: an experimental study in rats
| Autor: | Bernard Nordlinger, Recaredo Infante, K. Hillan, J. P. Puts, F. Ballet |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Colon medicine.medical_treatment Less invasive Statistical difference Anastomosis Hemoglobins Leukocyte Count medicine Animals Chemotherapy Wound Healing business.industry Anastomosis Surgical Body Weight Intraperitoneal chemotherapy Rats Inbred Strains Surgery Rats Colonic cancer Anesthesia Fluorouracil business Adjuvant Injections Intraperitoneal |
| Zdroj: | The Journal of surgical research. 44(2) |
| ISSN: | 0022-4804 |
| Popis: | Early postoperative intraperitoneal administration of 5-fluorouracil (5-Fu) is a logical adjuvant treatment of patients with resectable colonic cancers. It is easier and less invasive than the intraportal administration of the drug. However, before applying the procedure to humans it must be demonstrated than it does not disturb the healing of recent colonic anastomoses. Colonic sutures were performed in 78 male Wistar rats. The animals then either served as controls or received intraperitoneal 5-Fu during 5 days starting on the first, third, or seventh postoperative day. No statistical difference was observed between treated and control groups when observing the incidence of anastomotic spontaneous disruptures, anastomotic healing strength, or the weight of the animals. It is concluded that early intraperitoneal 5-Fu administration does not impair the healing of recent colonic anastomoses in rats. |
| Databáze: | OpenAIRE |
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