DNA Damage Baseline Predicts Resilience to Space Radiation and Radiotherapy
| Autor: | Antonella Bertucci, Ianik Plante, Sylvain V. Costes, Alejandra Lopez Macha, Jonathan Tang, Antony S. Tin, Egle Cekanaviciute, Eloise Pariset, Vanesa Gomez Gonzalez, Sherina Malkani, Margaux Petay, Ivan G. Paulino Lima, Marcelo Vazquez |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty DNA Repair DNA damage medicine.medical_treatment Endogeny Genotoxic Stress medicine.disease_cause Radiation Tolerance Article General Biochemistry Genetics and Molecular Biology Histones 03 medical and health sciences 0302 clinical medicine Immune system Radiation sensitivity Internal medicine Humans Medicine DNA Breaks Double-Stranded Aged Weightlessness business.industry Cancer Dose-Response Relationship Radiation DNA Middle Aged Space Flight Prognosis medicine.disease Radiation therapy Oxidative Stress 030104 developmental biology Female business 030217 neurology & neurosurgery Oxidative stress DNA Damage |
| Zdroj: | Cell reports |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2020.108434 |
| Popis: | SUMMARY Deep space exploration will require real-time, minimally invasive monitoring of astronaut health to mitigate the potential health impairments caused by space radiation and microgravity. Genotoxic stress in humans can be monitored by quantifying the amount of DNA double-strand breaks (DSBs) in immune cells from a simple finger prick. In a cohort of 674 healthy donors, we show that the endogenous level of DSBs increases with age and with latent cytomegalovirus infection. To map the range of human responses to space radiation, we then study DSB induction and repair in immune cells from 319 healthy donors after the cells are exposed to galactic cosmic ray components and lymphocytes from 30 cancer patients after radiotherapy. Individuals with low baseline DSB have fewer clinical complications, enhanced DNA damage repair responses, and a functional dose-dependent cytokine response in healthy donor cells. This supports the use of DSB monitoring for health resilience in space. Graphical Abstract In Brief Pariset et al. find that individuals with a lower baseline level of DNA damage are resilient to clinical complications after radiotherapy and present higher radiation-induced levels of DNA repair foci and inflammatory cytokines. These findings support the use of baseline DNA damage as a biomarker for radiation sensitivity. |
| Databáze: | OpenAIRE |
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