Cross-Reactivity of Primate Alloantigens: Absorption of Anti-HL-A Reactivity from Human Alloantisera by Chimpanzee Lymphocytes
| Autor: | Richard S. Metzgar, Reid Dm, Frances E. Ward, Hilliard F. Seigler |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Isoantigens
Pan troglodytes Lymphocyte Immunology Cross Reactions Biology medicine.disease_cause Biochemistry Cross-reactivity Isoantibodies Antibody Specificity Histocompatibility Antigens Genetics medicine Animals Humans Immunology and Allergy Cytotoxic T cell Hemadsorption Lymphocytes Cytotoxicity Antiserum Immune Sera General Medicine Histocompatibility medicine.anatomical_structure |
| Zdroj: | Tissue Antigens. 3:389-401 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.1973.tb00509.x |
| Popis: | Similarity between human and chimpanzee alloantigens was investigated by absorbing human alloantisera with chimpanzee lymphocytes and testing the absorbed antisera with appropriate HL–A-phenotyped human lymphocytes. Chimpanzee lymphocytes were consistently negative in cytotoxicity assays with monospecific human HL–A2, 3, 9, and 13 antisera. Chimpanzee lymphocytes failed to remove reactivity for these specificities in absorption studies. Positive cytotoxic reactions were observed with chimpanzee lymphocytes and anti-HL–A1, 11, 12, and W27 human alloantisera. Absorption with chimpanzee lymphocytes removed reactivity removed reactivity for these specificities as shown by tests with human lymphocytes of the appropriate HL–A phenotype. Non-specific absorption or a CYNAP-type phenomenon was seen in chimpanzee lymphocyte absorptions with anti-HL–A1, 5, and 11 antisera. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text