Male rats treated with subchronic PCP show intact olfaction and enhanced interest for a social odour in the olfactory habituation/dishabituation test
| Autor: | Emilia Tarland, Jan Brosda |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Olfactory system Time Factors Phencyclidine Sensory system Olfaction Rats Sprague-Dawley Random Allocation 03 medical and health sciences Behavioral Neuroscience Discrimination Psychological 0302 clinical medicine medicine Animals Habituation Habituation Psychophysiologic Social Behavior Motivation Psychological Tests business.industry Olfactory Perception medicine.disease Social relation 030227 psychiatry Disease Models Animal Schizophrenia Pattern Recognition Physiological Endophenotype Exploratory Behavior business Excitatory Amino Acid Antagonists Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Behavioural Brain Research. 345:13-20 |
| ISSN: | 0166-4328 |
| Popis: | The olfactory system participates in many sensory processes, and olfactory endophenotypes appear in a variety of neurological disorders such as Alzheimer's and Parkinson's disease, depression and schizophrenia. Social withdrawal is a core negative symptom of schizophrenia and animal models have proven to be invaluable for studying the neurobiological mechanisms and cognitive processes behind the formation of social relationships. The subchronic phencyclidine (PCP) rat model is a validated model for negative symptoms of schizophrenia, such as impaired sociability. However, the complete range of social behaviour and deficits in the model are still not fully understood. Intact rodent olfaction is essential for a wide range of social behaviour and disrupted olfactory function could have severe effects on social communication and recognition. In order to examine the olfactory ability of male rats treated with subchronic PCP, we conducted an olfactory habituation/dishabituation test including both non-social and social odours. The subchronic PCP-treated rats successfully recognized and discriminated among the odours, indicative of intact olfaction. Interestingly, the subchronic PCP-treated rats showed greater interest for a novel social odour compared to the saline-treated rats and the rationale remains to be elucidated. Our data indicate that subchronic PCP treatment does not disrupt olfactory function in male rats. By ruling out impaired olfaction as cause for the poor social interaction performance in subchronic PCP-treated rats, our data supports the use of NMDA receptor antagonists to model the negative symptoms of schizophrenia. |
| Databáze: | OpenAIRE |
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