Apelin attenuates depressive-like behavior and neuroinflammation in rats co-treated with chronic stress and lipopolysaccharide
| Autor: | E. Li, Jian-ping Yan, Zi-xuan Zhang, Pei Shen, Yong You, Shaowen Tian, Wan Fu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Lipopolysaccharide Central nervous system 030209 endocrinology & metabolism 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine medicine Animals Chronic stress Rats Wistar Neuroinflammation Inflammation Behavior Animal Endocrine and Autonomic Systems business.industry Depression NF-kappa B General Medicine Antidepressive Agents Apelin Rats Disease Models Animal medicine.anatomical_structure Neurology chemistry Astrocytes Antidepressant Microglia Cell activation business 030217 neurology & neurosurgery Stress Psychological Astrocyte Signal Transduction |
| Zdroj: | Neuropeptides. 77 |
| ISSN: | 1532-2785 |
| Popis: | Several experimental studies have proved that activation of neuroinflammation pathways may contribute to the development of depression, a neuropsychiatric disorder disease. Our previous studies have shown the antidepressant properties of apelin, but the mechanism was unkown. This study was performed to verify whether the antidepressant effect of apelin was related to its anti-inflammation effect in the central nervous system. To achieve our aim, we selected the co-treatment of chronic stress and LPS to induced an inflammatory process in rats. The effect of this co-treatment was evaluated through the expression of inflammatory markers and glial cell activation. LPS injection co-treated with unpredictable chronic mild stress resulted in the activation of microglial cell and astrocyte, expression of inflammatory markers and depressive behaviors. Treatment with apelin significantly attenuates the deleterious effects in these rats. Our results showed that apelin improved depressive phenotype and decreased the activation of glial cells in stress co-treatment group. The down-regulations of p-NF-κB and p-IKKβ suggested that the effects are possibly mediated by inhibition of the NF-κB-mediated inflammatory response. These findings speculated that intracerebroventricular injection of apelin could be a therapeutic approach for the treatment of depression, and the antidepressant function of apelin may closely associated with its alleviation in neuroinflammation. |
| Databáze: | OpenAIRE |
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