| Autor: |
Sabri, Soussi, Divya, Sharma, Peter, Jüni, Gerald, Lebovic, Laurent, Brochard, John C, Marshall, Patrick R, Lawler, Margaret, Herridge, Niall, Ferguson, Lorenzo, Del Sorbo, Elodie, Feliot, Alexandre, Mebazaa, Erica, Acton, Jason N, Kennedy, Wei, Xu, Etienne, Gayat, Claudia C, Dos Santos |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Critical care (London, England). 26(1) |
| ISSN: |
1466-609X |
| Popis: |
Background Late mortality risk in sepsis-survivors persists for years with high readmission rates and low quality of life. The present study seeks to link the clinical sepsis-survivors heterogeneity with distinct biological profiles at ICU discharge and late adverse events using an unsupervised analysis. Methods In the original FROG-ICU prospective, observational, multicenter study, intensive care unit (ICU) patients with sepsis on admission (Sepsis-3) were identified (N = 655). Among them, 467 were discharged alive from the ICU and included in the current study. Latent class analysis was applied to identify distinct sepsis-survivors clinical classes using readily available data at ICU discharge. The primary endpoint was one-year mortality after ICU discharge. Results At ICU discharge, two distinct subtypes were identified (A and B) using 15 readily available clinical and biological variables. Patients assigned to subtype B (48% of the studied population) had more impaired cardiovascular and kidney functions, hematological disorders and inflammation at ICU discharge than subtype A. Sepsis-survivors in subtype B had significantly higher one-year mortality compared to subtype A (respectively, 34% vs 16%, p p = 0.006). Conclusions A subtype with sustained organ failure and inflammation at ICU discharge can be identified from routine clinical and laboratory data and is independently associated with poor long-term outcome in sepsis-survivors. Trial registration NCT01367093; https://clinicaltrials.gov/ct2/show/NCT01367093. Graphical Abstract |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink