Propranolol eye drops in patients with corneal neovascularization
| Autor: | Pina Fortunato, Luca Filippi, Barbara Zamma Gallarati, Cinzia de Libero, Elena Piozzi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Visual acuity genetic structures Photophobia Vasodilator Agents Propranolol Beta-blockers Stevens–Johnson syndrome Toxic epidermal necrolysis Neovascularization beta-blockers 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine toxic epidermal necrolysis Ophthalmology Humans Medicine Effective treatment Corneal Neovascularization In patient Clinical Case Report Child Adverse effect business.industry General Medicine medicine.disease eye diseases Treatment Outcome Child Preschool Stevens-Johnson Syndrome Corneal neovascularization 030221 ophthalmology & optometry Female sense organs Ophthalmic Solutions medicine.symptom business Research Article medicine.drug |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000013002 |
| Popis: | Rationale: Studies performed in animal models of corneal neovascularization suggested the possible efficacy of a treatment with propranolol. Corneal neovascularization is one of the most feared complications of Stevens–Johnson syndrome that frequently involves ocular surface. We report the first 2 patients with severe ocular neo-vascularization treated with different degrees of success, with propranolol eye drops. Patient concerns: Two patients with corneal neovascularization complicating the Stevens–Johnson syndrome, not responsive to steroids and cyclosporine, were treated with propranolol eye drops. Diagnoses: Corneal neovascularization was detected by ophthalmoscopic evaluation. Interventions: Topical treatment with propranolol eye drops at different concentrations. Outcomes: Both patients reported dramatic subjective benefits (reduction of photophobia and discomfort) without adverse effects, and in the patient with a less advanced disease, an objective reduction of neovascularization and an improved visual acuity was observed. Lessons: This experience suggests that propranolol might be an inexpensive, safe and effective treatment in counteracting the progression of corneal neovascularization. |
| Databáze: | OpenAIRE |
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