Peripheral nerve vascular changes in spontaneously hypertensive rats
| Autor: | Francesco Amenta, Maurizio Sabbatini, José A. Vega |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Cerebral arteries Ischemia Blood Pressure Rats Inbred WKY Internal medicine Rats Inbred SHR Vasa nervorum Peripheral Nervous System medicine Animals business.industry General Neuroscience Microcirculation Body Weight Anatomy medicine.disease Sciatic Nerve Rats medicine.anatomical_structure Blood pressure Regional Blood Flow Circulatory system Hypertension Cardiology sense organs Sciatic nerve business Blood vessel Artery |
| Zdroj: | Neuroscience letters. 217(2-3) |
| ISSN: | 0304-3940 |
| Popis: | Circulation to the brain is affected by hypertension. Hypertension-dependent cerebrovascular changes were documented primarily in brain pial arteries, whereas no information is so far available concerning changes of peripheral nerve vascularization in hypertension. This study was designed to assess the occurrence of structural changes of interfascicular and intrafascicular arteries supplying peripheral nerves (the so called vasa nervorum) in spontaneously hypertensive rats (SHR). The investigation was performed in 8-month-old SHR, by using standard microanatomical techniques associated with quantitative image analysis. In SHR a significant increase of systolic pressure values accompanied by thickening of the arterial wall, narrowing of the lumen and increase of the wall-to-lumen ratio were observed in comparison with age-matched normotensive Wistar-Kyoto rats. Hypertension-related structural changes involved primarily interfascicular arteries and to a lesser extent intrafascicular arteries. These findings indicate that similarly as documented for cerebral arteries, the vascular supply to peripheral nerves is impaired in hypertension. Structural changes of interfascicular and intrafascicular arteries of SHR could lead to ischemia of peripheral nerves. Further work is in progress to evaluate the functional relevance of hypertensive changes to peripheral nerve vasculature. |
| Databáze: | OpenAIRE |
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