Racial, Ethnic, and Age Disparities in Incidence and Survival of Intrahepatic Cholangiocarcinoma in the United States; 1995-2014

Autor: Esther Buzaglo Dantas-Corrêa, Carina Gabriela Correa, Giovana Denardin, Mariana Costa-Silva, Maria L. Ayres Alencar, Janaína Luz Narciso-Schiavon, Maria Luiza-Bazzo, Leonardo de Lucca Schiavon, David Alejandro González-Chica, Letícia Muraro-Wildner, Mara Sérgia Pacheco Honório Coelho, Telma Erotides Silva
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Alcoholic liver disease
Cirrhosis
Time Factors
Survival
Ethnic group
Specialties of internal medicine
Gastroenterology
Cholangiocarcinoma
0302 clinical medicine
Risk Factors
Epidemiology
Ethnicity
Outpatient clinic
Medicine
Prospective cohort study
Serum adiponectin
Intrahepatic Cholangiocarcinoma
Intrahepatic cholangiocarcinoma
education.field_of_study
Incidence (epidemiology)
Incidence
Hazard ratio
General Medicine
Middle Aged
Prognosis
Racial ethnic
RC581-951
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Female
hormones
hormone substitutes
and hormone antagonists
Adult
medicine.medical_specialty
Race
Adolescent
Population
03 medical and health sciences
Young Adult
Age Distribution
Internal medicine
Humans
Clinical significance
Sex Distribution
education
Aged
Adiponectin
Hepatology
business.industry
Racial Groups
nutritional and metabolic diseases
Health Status Disparities
medicine.disease
Confidence interval
United States
SEER
Bile Duct Neoplasms
Resistin
business
Demography
SEER Program
Zdroj: Annals of Hepatology, Vol 17, Iss 4, Pp 604-614 (2018)
Annals of Hepatology, Vol 17, Iss 2, Pp 274-285 (2018)
ISSN: 1665-2681
Popis: Introduction Adiponectin and resistin levels are increased in patients with cirrhosis, but it prognostic significance is unknown. We sought to investigate the factors associated with adiponectin and resistin levels and its clinical significance in patients with cirrhosis. Materials and methods This was a prospective cohort study that included 122 subjects with cirrhosis who attended an outpatient clinic and were initially evaluated in 2012. Serum adiponectin and resistin levels were measured in samples collected in 2012 (adiponectin and resistin) and 2014 (adiponectin). Thirty healthy subjects served as a control group. Results Higher adiponectin (21.59 μ g/mL vs. 12.52 μg/mL, P l 0.001) and resistin levels (3.83 ng/mL vs. 2.66 ng/mL, P l 0.001) were observed among patients with cirrhosis compared to controls. Patients classified as Child-Pugh B/C had higher adiponectin levels in relation to Child-Pugh A patients. At second measurement, adiponectin levels increased significantly in non-transplant patients and decreased in liver transplant recipients. Univariate Cox analysis showed that among patients with alcoholic liver disease, adiponectin levels were associated with lower transplant-free survival (HR = 1.034, 95% CI 1.006 - 1.062, P = 0.016). The transplant-free survival was significantly lower among patients with alcoholic liver disease and adiponectin ≥ 17 μg/mL (26.55 months, 95% CI 21.40-31.70) as compared to those with levels l 17 μg/mL (33.76 months, 95% CI 30.70-36.82) (P = 0.045). No relationship was found between the levels of resistin and survival. Conclusion Adiponectin but not resistin levels were associated with intensity of liver dysfunction and worse prognosis in patients with alcoholic liver disease, suggesting a potential as a prognostic biomarker.
Databáze: OpenAIRE
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