Vascular stiffness in familial hypercholesterolaemia is associated with C-reactive protein and cholesterol burden
| Autor: | Hao Min Cheng, Z. X. Ye, K. R. Chiou, Shing Jong Lin, Min-Ji Charng |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypercholesterolemia Clinical Biochemistry Biochemistry High cholesterol chemistry.chemical_compound Risk Factors Internal medicine Humans Medicine cardiovascular diseases Pulse wave velocity Coronary atherosclerosis biology business.industry Cholesterol C-reactive protein Case-control study General Medicine Atherosclerosis medicine.disease Elasticity Pedigree C-Reactive Protein medicine.anatomical_structure Endocrinology chemistry Case-Control Studies cardiovascular system biology.protein Arterial stiffness Cardiology Female Vascular Resistance Tunica Intima business Artery |
| Zdroj: | European Journal of Clinical Investigation. 37:197-206 |
| ISSN: | 1365-2362 0014-2972 |
| Popis: | Background Familial hypercholesterolaemia (FH) is characterized by very high serum cholesterol and premature coronary atherosclerosis. Arterial stiffness and atherosclerosis are two major underlying pathophysiologies of arterial disease that are predictive of future cardiovascular events. The aims of this study were to quantify atherosclerosis and arterial stiffness and to evaluate their relationship with high sensitive C-reactive protein (hs-CRP) and the level of exposure to high serum cholesterol in FH patients. Materials and methods We measured traditional risk factors, hs-CRP, intima-media thickness (IMT) of carotid artery, and brachial-ankle pulse wave velocity (baPWV) in 35 heterozygous FH subjects and 17 healthy control subjects. Cholesterol-year score (CYS) was calculated to estimate the lifetime cholesterol burden in FH subjects. Results FH subjects had significantly elevated total cholesterol, low-density lipoprotein cholesterol, and carotid IMT compared with those without mutations. Among FH patients, the baPWV and carotid IMT were higher in cases with high cholesterol burden than those without. Similarly, the baPWV and carotid IMT were also higher in cases with elevated hs-CRP (> 1 mg L−1) than those without. Multiple linear regression analysis demonstrated CYS and hs-CRP were significant independent predictors of baPWV and IMT in FH patients. Conclusions Both high cholesterol burden and vascular inflammation are not only associated with atherosclerosis, but also contribute to the development of arterial stiffness in FH patients. Early detection of hypercholesterolaemia in FH patients is warranted to prevent the untoward pathophysiologies. |
| Databáze: | OpenAIRE |
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