Expression of c-myb in embryonal carcinoma cells and embryonal stem cells
| Autor: | P. Julian Dyson, F. Poirier, Roger J. Watson |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Cancer Research
animal structures Embryonal Carcinoma Stem Cells Transcription Genetic Cellular differentiation Gene Expression Embryoid body Biology Embryonal carcinoma Mice Proto-Oncogene Proteins c-myb Proto-Oncogene Proteins medicine Tumor Cells Cultured Animals Deoxyribonuclease I MYB Molecular Biology fungi Cell Biology Neoplasms Germ Cell and Embryonal medicine.disease Molecular biology Embryonic stem cell Chromatin Hematopoiesis Haematopoiesis Neoplastic Stem Cells RNA Stem cell Developmental Biology |
| Zdroj: | Differentiation; research in biological diversity. 42(1) |
| ISSN: | 0301-4681 |
| Popis: | Mouse c-myb has ben implicated in the regulation of differentiation and proliferation of haematopoietic cells. Analysis of the chromatin structure of the promoter region of c-myb in embryonal carcinoma (EC) cells and embryonal stem (ES) cells reveals a DNAse I-hypersensitive site coincident with a site found in c-myb-expressing haematopoietic cells, but absent in murine fibroblasts (which do not express c-myb). EC and ES cells were found to express c-myb mRNA, albeit at a level lower than found in haematopoietic cells. Differentiation of ES cells into embryoid bodies resulted in an elevated level of c-myb expression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text