A Prospective Study Comparing Human Metapneumovirus with Other Respiratory Viruses in Adults with Hematologic Malignancies and Respiratory Tract Infections
| Autor: | Magdalena Otegui, Rocío Parody, Nuria Rabella, John V. Williams, James E. Crowe, Rodrigo Martino, Joshua M. Heck |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty viruses medicine.medical_treatment Paramyxoviridae Infections Hematopoietic stem cell transplantation Biology Article Human metapneumovirus Internal medicine medicine Humans Immunology and Allergy Metapneumovirus Prospective Studies Prospective cohort study Respiratory Tract Infections Aged Respiratory tract infections Hematopoietic Stem Cell Transplantation virus diseases Respiratory infection Middle Aged biology.organism_classification respiratory tract diseases Infectious Diseases medicine.anatomical_structure Hematologic Neoplasms Immunology Female Respiratory tract |
| Zdroj: | The Journal of Infectious Diseases. 192:1061-1065 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/432732 |
| Popis: | Human metapneumovirus (hMPV) is a recently described paramyxovirus associated with upper and lower respiratory-tract infection (URI and LRI, respectively). We conducted a prospective study of URI and LRI in adults with hematologic malignancies during a 4-year period. We retrospectively tested samples by reverse-transcription polymerase chain reaction for hMPV and analyzed clinical data. Twenty-two (9%) of 251 episodes of respiratory infection tested positive for hMPV. Sixteen (73%) of the illnesses occurred in hematopoietic stem-cell transplant recipients. Nine patients with hMPV developed LRI; 3 of these patients died. hMPV is a common cause of respiratory infections in adults with hematologic malignancies, with associated morbidity and mortality. |
| Databáze: | OpenAIRE |
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