Toll-like receptor and cytokine expression throughout the bone marrow differs between patients with low- and high-risk myelodysplastic syndromes

Autor:	Luana Chiquetto Paracatu, Darlene A. Monlish, Zev J. Greenberg, Daniel A.C. Fisher, Matthew J. Walter, Stephen T. Oh, Laura G. Schuettpelz
Rok vydání:	2021
Předmět:	Cancer Research Toll-Like Receptors Cell Biology Hematology Toll-Like Receptor 1 Toll-Like Receptor 2 Toll-Like Receptor 6 Bone Marrow Transforming Growth Factor beta Myelodysplastic Syndromes Genetics Cytokines Humans Molecular Biology
Zdroj:	Experimental hematology. 110
ISSN:	1873-2399
Popis:	Myelodysplastic syndromes (MDS) are hematopoietic stem cell disorders, the pathogenesis of which involves enhanced immune signaling that promotes or selects for mutant hematopoietic stem and progenitor cells (HSPCs). In particular, toll-like receptor (TLR) expression and signaling are enhanced in MDS, and their inhibition is an attractive therapeutic strategy. Although prior studies have reported increased expression of TLR2 and its binding partners TLR1 and TLR6 in the CD34
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f6fb66b6c2f9c99beb941a87231e30 https://pubmed.ncbi.nlm.nih.gov/35367529 Zobrazit plný text záznamu Full Text from ScienceDirect