Meteorin Is a Novel Therapeutic Target for Wet Age-Related Macular Degeneration
| Autor: | Min Zhao, Alexandre Moulin, Marie-Christine Naud, Virginie Dinet, Jérémie Canonica, Francine Behar-Cohen, Patricia Crisanti-Lassiaz, Alexandre Sellam, Kimberley Delaunay, Emmanuelle Gelize |
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| Přispěvatelé: | HAL-SU, Gestionnaire, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases, Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lausanne = University of Lausanne (UNIL), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Université de Lausanne (UNIL) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty retina therapeutic innovation genetic structures Angiogenesis meteorin Neuroprotection choroidal neovascularization Article 03 medical and health sciences angiogenesis 0302 clinical medicine In vivo medicine [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs Retina medicine.diagnostic_test business.industry General Medicine Fluorescein angiography eye diseases 030104 developmental biology medicine.anatomical_structure Choroidal neovascularization [SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology 030221 ophthalmology & optometry [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology Medicine Choroid sense organs medicine.symptom business Ex vivo |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, 2021, 10 (13), pp.2973. ⟨10.3390/jcm10132973⟩ Journal of clinical medicine, vol. 10, no. 13, pp. 2973 Journal of Clinical Medicine, MDPI, 2021, 10 (13), pp.2973. ⟨10.3390/jcm10132973⟩ Journal of Clinical Medicine, Vol 10, Iss 2973, p 2973 (2021) Volume 10 Issue 13 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10132973⟩ |
| Popis: | International audience; The aim of this study was to evaluate the potential anti-angiogenic effect of MTRN (meteorin) in the laser-induced CNV rat model and explore its mechanisms of action. MTRN, thrompospondin-1, glial cell markers (GFAP, vimentin), and phalloidin were immuno-stained in non-human primate flat-mounted retinas and human retina cross sections. The effect of MTRN at different doses and time points was evaluated on laser-induced CNV at 14 days using in vivo fluorescein angiography and ex vivo quantification of CNV. A pan transcriptomic analysis of the retina and the RPE/choroid complex was used to explore MTRN effects mechanisms. In human retina, MTRN is enriched in the macula, expressed in and secreted by glial cells, and located in photoreceptor cells, including in nuclear bodies. Intravitreal MTRN administered preventively reduced CNV angiographic scores and CNV size in a dose-dependent manner. The highest dose, administered at day 7, also reduced CNV. MTRN, which is regulated by mineralocorticoid receptor modulators in the rat retina, regulates pathways associated with angiogenesis, oxidative stress, and neuroprotection. MTRN is a potential novel therapeutic candidate protein for wet AMD. |
| Databáze: | OpenAIRE |
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