Serum 8-OHdG and HIF-1 levels: do they affect the development of malignancy in patients with hypoactive thyroid nodules?
| Autor: | Harman Mustafa, Karadeniz Muammer, Cetinkalp Sevki, Erdogan Mehmet, Biray Avci Cigir, Gunduz Cumhur, Dodurga Yavuz, Saygılı Fusun, Ozgen Ahmet Gokhan, Harman Ece |
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| Přispěvatelé: | Ege Üniversitesi |
| Rok vydání: | 2013 |
| Předmět: |
Thyroid nodules
endocrine system medicine.medical_specialty endocrine system diseases HIF-1? HIF-1α Urine Malignancy Gastroenterology Thyroiditis Pathogenesis Internal medicine Biopsy medicine hypoactive thyroid nodule Radiology Nuclear Medicine and imaging Original Paper medicine.diagnostic_test business.industry HIF-1 alpha Thyroid Cancer medicine.disease medicine.anatomical_structure Endocrinology Oncology business 8-OHdG |
| Zdroj: | Contemporary Oncology |
| ISSN: | 1428-2526 |
| DOI: | 10.5114/wo.2013.33774 |
| Popis: | WOS: 000316428000010 Aim of the study: This study aimed to evaluate 8-OHdG and hypoxia-inducible factor 1 (HIF-1 alpha) levels in patients with hypoactive thyroid nodules (toxic multinodular goiter, Graves' disease, and Hashimoto's thyroiditis), as these parameters may be related to oxidative stress and the pathogenesis of cancer. Material and methods: The study included patients diagnosed with Graves' disease (n = 20), toxic multinodular goiter (n = 20), and Hashimoto thyroiditis (n = 20), and 20 healthy Controls. HIF-1 alpha levels were measured in blood samples and 8-OHdG levels were measured in urine - both via ELISA. Results: HIF-1 alpha, and 8-OHdG levels were significantly higher in the patient groups than in the control group (p < 0.05). In the Hashimoto's thyroiditis patients a correlation was observed between 8-OHdG and thyroglobulin antibodies (p = 0.03). A significant relation was found between 8-OHdG and HIF-1 alpha in the patient group (p < 0.01). Carcinoma was detected in 7 of 43 female patients, but not in any of the male patients. No difference was observed in 8-OHdG or HIF-1 alpha levels between the patients with and without papillary carcinoma (p > 0.05). There was no significant difference in 8-OHdG or HIF-1 alpha levels between the patients with biopsy results that were benign, malignant, and non-diagnostic (p > 0.05). Conclusions: Serum HIF-1 alpha and urine 8-OHdG levels were significantly higher in the patients with thyroid diseases; however, a relationship with cancer was not observed. |
| Databáze: | OpenAIRE |
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