The evaluation of sterile solutions of Ilwensisaponin A and C from Verbascum pterocalycinum var. mutense Hub.-Mor. on antiviral, antinociceptive and anti-inflammatory activities
| Autor: | Zeliha S. Akdemir, İlyas Çankaya, M. Taner Karaoglu, N. Yagmur Diker, Cigdem Kahraman, Tansel Comoglu, Esra Küpeli Akkol |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
Traditional medicine biology Strain (chemistry) medicine.drug_class Chemistry lcsh:RM1-950 Pharmaceutical Science biology.organism_classification Anti-inflammatory Acute toxicity Carrageenan chemistry.chemical_compound Nociception lcsh:Therapeutics. Pharmacology medicine Verbascum biology.protein Cytotoxic T cell Cyclooxygenase |
| Zdroj: | Saudi Pharmaceutical Journal, Vol 27, Iss 3, Pp 432-436 (2019) |
| ISSN: | 1319-0164 |
| Popis: | Antiviral, antinociceptive and anti-inflammatory activities of the 1% sterile solutions of Ilwensisaponin A and C isolated from the methanolic extract of the flowers of Verbascum pterocalycinum var. mutense Hub.-Mor. were investigated. Antiviral activities of sterile solutions were evaluated against Bovine Herpes Virus Type-1 (BHV-1) (Cooper strain). Both solutions showed cytotoxic effects. However, none of the sterile solutions showed antiviral activity with CPE values. Anti-inflammatory and antinociceptive response were obtained at doses of 100 mg/kg. The results of the evaluation of the anti-inflammatory activities induced by carrageenan showed that these sterile solutions possess active constituents and diminish cyclooxygenase activitiy. In addition, antinociceptive activities using p-benzoquinone-induced writhing model in mice of tested solutions were found to show notable activity in statistical analysis without inducing any apparent acute toxicity as well as gastric damage. To the best of our knowledge, this study is the first investigation of antiviral, anti-inflammatory and antinociceptive activities of sterile solutions of Ilwensisaponin A and C isolated from Verbascum pterocalycinum var. mutense Hub.-Mor. growing in Turkey. Keywords: Ilwensisaponin A, Ilwensisaponin C, Verbascum, Antiviral activity, Anti-inflammatory activity, Sterile solution |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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