Colorectal cancer specific conditions promote Streptococcus gallolyticus gut colonization

Autor: Céline Mulet, Laetitia Aymeric, Philippe J. Sansonetti, Claire Poyart, Marion Bérard, Shaynoor Dramsi, Azadeh Saffarian, Béatrice Regnault, Patrick Trieu-Cuot, Laurence du Merle, Françoise Donnadieu, Giulia Nigro, Sylvie Robine
Přispěvatelé: Pathogénie microbienne moléculaire, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie des Bactéries pathogènes à Gram-positif, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Animalerie centrale (Plate-forme), Institut Pasteur [Paris] (IP), Centre national de Référence des Streptocoques (CNR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Barrières et Pathogènes, [Institut Cochin] Departement Infection, immunité, inflammation, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut thématique multiorganismes Biologie Cellulaire, Développement et Evolution (ITMO BCDE), Alliance Nationale pour les Sciences de la vie et de la Santé [Paris] (AVIESAN), Génotypage des Eucaryotes (Plate-Forme), Collège de France - Chaire Microbiologie et Maladies infectieuses, Collège de France (CdF (institution)), This work was funded by La Ligue Nationale contre le Cancer, Association pour la Recherche sur le Cancer Foundation, the Research Applications and Industrial Partnerships Department of Pasteur Institute, the European Research Council (ERC), the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence 'Integrative Biology of Emerging Infectious Diseases' Grant ANR-10-LABX-62-IBEID, ERC Grant DECRYPT 2013-ADG 339579 (to P.J.S.), and a gift from ONET Company. L.A. was supported by La Ligue Nationale contre le Cancer for 3 y and by ERC for 18 mo. P.J.S. is a Senior Foreign Scholar of the Howard Hughes Medical Institute., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 339579,EC:FP7:ERC,ERC-2013-ADG,DECRYPT(2014), Nigro, Giulia, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, Decrypting signals in the crypt. - DECRYPT - - EC:FP7:ERC2014-04-01 - 2019-03-31 - 339579 - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris], Chaire Microbiologie et Maladies infectieuses
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
MESH: Symporters
Colorectal cancer
medicine.drug_class
[SDV]Life Sciences [q-bio]
colorectal cancer
[SDV.CAN]Life Sciences [q-bio]/Cancer
MESH: Bile Acids and Salts
Biology
Microbiology
03 medical and health sciences
0302 clinical medicine
S. bovis
MESH: Bacteriocins
Bacteriocin
bacteriocin
[SDV.CAN] Life Sciences [q-bio]/Cancer
medicine
Streptococcus gallolyticus
Colonization
MESH: Animals
MESH: Streptococcus gallolyticus
MESH: Mice
2. Zero hunger
SLC10A2
MESH: Adenoma
MESH: Organic Anion Transporters
Sodium-Dependent
Multidisciplinary
MESH: Humans
Bile acid
Wnt signaling pathway
medicine.disease
MESH: Gene Expression Regulation
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
In vitro
digestive system diseases
[SDV] Life Sciences [q-bio]
030104 developmental biology
APC/Notch
030220 oncology & carcinogenesis
biology.protein
MESH: Gastrointestinal Tract
S. gallolyticus
[SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
MESH: Receptors
Notch
MESH: Colorectal Neoplasms
Zdroj: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (2), pp.E283-E291. ⟨10.1073/pnas.1715112115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (2), pp.E283-E291. ⟨10.1073/pnas.1715112115⟩
ISSN: 0027-8424
1091-6490
DOI: 10.1073/pnas.1715112115⟩
Popis: Significance Growing evidence indicates a correlation between colorectal cancer and intestinal dysbiosis or colonization by single bacterial species such as Streptococcus gallolyticus subsp. gallolyticus (SGG), yet a causality link remains to be established. To address this point experimentally, we colonized Apc +/ − Notch-inducible mice with SGG. Apc +/ − is a pioneer somatic mutation driving the occurrence of polyps. We did not observe significant changes in the occurrence or development of polyps in this model. However, we observed a strong SGG colonization in Apc +/ − mice at the expense of resident enterococci. We related this ecological substitution to activation of a SGG-specific bacteriocin whose activity is induced in vivo by the detergent effect of an increased concentration of secondary bile acids in relation to oncogenic situation.
Databáze: OpenAIRE
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