Disrupted dynamic functional connectivity in right amygdalar subregions differentiates bipolar disorder from major depressive disorder
| Autor: | Di Li, Qian Cui, Zongling He, Ahmed Ameen Fateh, Yang Yang, Huafu Chen, Xujun Duan, Yuyan Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Cerebellum Bipolar Disorder Neuroscience (miscellaneous) Emotional processing Amygdala 03 medical and health sciences 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Bipolar disorder Dynamic functional connectivity Depressive Disorder Major medicine.diagnostic_test business.industry Somatosensory Cortex Middle Aged medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Major depressive disorder Female Analysis of variance Functional magnetic resonance imaging business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Psychiatry Research: Neuroimaging. 304:111149 |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/j.pscychresns.2020.111149 |
| Popis: | Notwithstanding being the object of a growing field of clinical research, the investigation of the dynamic resting-state functional connectivity alterations in psychiatric illnesses is still in its early days. Current research on major depressive disorder (MDD) and bipolar disorder (BD) has evidenced abnormal resting-state functional connectivity (rsFC), especially in regions subserving emotional processing and regulation such as the amygdala. However, dynamic changes in functional connectivity within the amygdalar subregions in distinguishing BD and MDD has not yet been fully understood. In this paper, we aim at analyzing the patterns characterizing dynamic FC (dFC) in the right amygdala to investigate the differences between similarly depressed BD and MDD. A number of 40 BD patients, 61 MDD patients and 63 healthy controls (HCs) underwent functional magnetic resonance imaging (fMRI) at rest. Using the right-amygdala as seed region, we compared the dFC within three subdivisions, namely, laterobasal (LB), centromedial (CM) and superficial (SF) between all the groups. To do so, one-way ANOVA followed by post-hoc t-tests were employed. Compared to HCs, patients with BD had a decreased dFC between right LB and the left postcentral gyrus as well as an increased dFC between right CM and the right cerebellum.Compared to BD patients, patients with MDD showed a decreased dFC between right CM and the cerebellum and an increased dFC between right LB and the left postcentral gyrus. These findings present initial evidence that abnormal patterns of the right-amygdalar subregions shared by BD and MDD supports the differential pathophysiology of these disorders. |
| Databáze: | OpenAIRE |
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