Exhaled nitric oxide and sputum eosinophil markers of inflammation in asthmatic children
| Autor: | Giorgio Piacentini, S Sperandio, Alessandro Bodini, Silvia Costella, A. L. Boner, L. Vicentini, Paola Mazzi |
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| Rok vydání: | 1999 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adolescent eosinophil sputum Nitric Oxide Leukocyte Count Ribonucleases fluids and secretions children Forced Expiratory Volume Humans Medicine Expiration Child Asthma Inflammation Eosinophil cationic protein Inhalation exhaled nitric oxide business.industry Respiratory disease Sputum Blood Proteins Eosinophil Granule Proteins respiratory system Eosinophil medicine.disease respiratory tract diseases Eosinophils Cross-Sectional Studies medicine.anatomical_structure Breath Tests Exhaled nitric oxide Immunology Inflammation Mediators medicine.symptom business |
| Zdroj: | European Respiratory Journal. 13:1386-1390 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.99.13613919 |
| Popis: | Exhaled nitric oxide and eosinophil sputum markers are considered noninvasive ways in which to evaluate airway inflammation in asthma. The aim of this study was to evaluate the relationships between these methods of evaluation in asthmatic children. In a cross-sectional study of 25 mild-moderate asthmatic children (aged 6-13 yrs, 10 patients on inhaled steroids) exhaled NO was measured along with induced sputum by inhalation of hypertonic saline solution. The sputum was processed for eosinophil count and eosinophil cationic protein (ECP) determination. Serum ECP and lung function (forced expiratory volume in one second (FEV1)) were also measured. A significant correlation was observed between exhaled NO and sputum eosinophils (r = 0.438, p = 0.032) as well as between sputum eosinophils and sputum ECP (r = 0.532, p |
| Databáze: | OpenAIRE |
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