Measurement of stretch-evoked brainstem function using fMRI
| Autor: | Andria J. Farrens, David Ress, Fabrizio Sergi, Andrea Zonnino |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Science Electromyography Article 050105 experimental psychology Midbrain 03 medical and health sciences Neural activity Young Adult 0302 clinical medicine Cerebellum Reaction Time Medicine Animals Humans 0501 psychology and cognitive sciences Muscle Skeletal Medulla Neurons Medulla Oblongata Multidisciplinary medicine.diagnostic_test business.industry 05 social sciences Motor Cortex Reticulospinal tract Magnetic Resonance Imaging Pons medicine.anatomical_structure Spinal Cord Female Brainstem business Functional magnetic resonance imaging Biomedical engineering Neuroscience 030217 neurology & neurosurgery Motor cortex Brain Stem |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Knowledge on the organization of motor function in the reticulospinal tract (RST) is limited by the lack of methods for measuring RST function in humans. Behavioral studies suggest the involvement of the RST in long latency responses (LLRs). LLRs, elicited by precisely controlled perturbations, can therefore act as a viable paradigm to measure motor-related RST activity using functional Magnetic Resonance Imaging (fMRI).Here we present StretchfMRI, a novel technique developed to study RST function associated with LLRs. StretchfMRI combines robotic perturbations with electromyography and fMRI to simultaneously quantify muscular and neural activity during stretch-evoked LLRs without loss of reliability. Using StretchfMRI, we established the muscle-specific organization of LLR activity in the brainstem. The observed organization is partially consistent with animal models, with activity primarily in the ipsilateral medulla for flexors and in the contralateral pons for extensors, but also include other areas, such as the midbrain and bilateral pontomedullary contributions. |
| Databáze: | OpenAIRE |
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