The Canonical Wnt Pathway Regulates Retinal Stem Cells/Progenitors in Concert with Notch Signaling
| Autor: | Iqbal Ahmad, Kavita Mallya, Ani V. Das, James D. Eudy, Xing Zhao, Ganapati V. Hegde, Sumitra Bhattacharya |
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| Rok vydání: | 2008 |
| Předmět: |
Lymphoid Enhancer-Binding Factor 1
Cellular differentiation Notch signaling pathway Chick Embryo Biology Retinal ganglion Retina Rats Sprague-Dawley Developmental Neuroscience Pregnancy Animals Cell Proliferation Oligonucleotide Array Sequence Analysis Induced stem cells Receptors Notch Stem Cells Wnt signaling pathway LRP6 Cell Differentiation LRP5 Rats Cell biology Wnt Proteins Neurology Hes3 signaling axis Female Signal Transduction |
| Zdroj: | Developmental Neuroscience. 30:389-409 |
| ISSN: | 1421-9859 0378-5866 |
| DOI: | 10.1159/000178017 |
| Popis: | The canonical Wnt pathway is known to influence multiple developmental events such as patterning, cell proliferation and cell specification. Recent studies have provided evidence of the involvement of the canonical Wnt pathway in the emergence and development of the optic neuroepithelium and its derivatives, particularly the retina. However, the mechanism of its action during retinal development remains rather obscure. Here, we demonstrate that (in agreement with observations in the blood, intestine, and skin) the canonical Wnt pathway influences retinal development by maintaining stem cells/progenitors. For example, the activation of this pathway keeps the early retinal stem cells/progenitors proliferating and uncommitted, while its attenuation facilitates their differentiation into retinal ganglion cells in vitro and in vivo. In addition, we demonstrate that Wnt signaling acts in concert with Notch signaling during retinal histogenesis, where the latter calibrates the influence of the former on the differentiation status of retinal stem cells/progenitors by regulating Lef1 and sFRP2. |
| Databáze: | OpenAIRE |
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