Murine cytomegalovirus myocarditis
| Autor: | J. E. Craighead, S. A. Huber, W. B. Martin |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Pathology medicine.medical_specialty Myocarditis medicine.drug_class Helper T lymphocyte Congenital cytomegalovirus infection Cytomegalovirus medicine.disease_cause Monoclonal antibody Herpesviridae Mice Betaherpesvirinae medicine Animals Hypersensitivity Delayed Mice Inbred BALB C biology business.industry Antibodies Monoclonal T-Lymphocytes Helper-Inducer medicine.disease biology.organism_classification Disease Models Animal medicine.anatomical_structure Delayed hypersensitivity Immunology CD4 Antigens Cytomegalovirus Infections Bone marrow Cardiology and Cardiovascular Medicine business |
| Zdroj: | European heart journal. 12 |
| ISSN: | 0195-668X |
| Popis: | Murine cytomegalovirus infects a variety of organs after inoculation into adult male mice. We have established a model of myocarditis in which focal lesions form adjacent to virus-infected endothelial cells. The development of the myocarditis is mediated by CD4+ helper T cells. The lesions fail to develop when these cells are eliminated from the animal by administration of a specific monoclonal antibody. Alternatively, repletion of thymectomized, irradiated and bone-marrow reconstituted animals with CD4+ cells results in myocarditis. The evidence, although incomplete, suggests that a delayed hypersensitivity response is the pathogenetic mechanism involved. |
| Databáze: | OpenAIRE |
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