Anti-persister and Anti-biofilm Activity of Self-Assembled Antimicrobial Peptoid Ellipsoidal Micelles

Autor: Jennifer S. Lin, Laurent A. Bekale, Natalia Molchanova, Josefine Eilsø Nielsen, Megan Wright, Brian Bacacao, Gill Diamond, Håvard Jenssen, Peter L. Santa Maria, Annelise E. Barron
Rok vydání: 2022
Předmět:
Zdroj: ACS Infectious Diseases. 8:1823-1830
ISSN: 2373-8227
DOI: 10.1021/acsinfecdis.2c00288
Popis: Although persister cells are the root cause of resistance development and relapse of chronic infections, more attention has been focused on developing antimicrobial agents against resistant bacterial strains than on developing anti-persister agents. Frustratingly, the global preclinical antibacterial pipeline does not include any anti-persister drug. Therefore, the central point of this work is to explore antimicrobial peptidomimetics called peptoids (sequence-specific oligo
Databáze: OpenAIRE