Advantages of the Alpha-lipoic Acid Association with Chlorpromazine in a Model of Schizophrenia Induced by Ketamine in Rats: Behavioral and Oxidative Stress evidences
| Autor: | Danielle Silveira Macêdo, Manoel Cláudio Azevedo Patrocínio, Jamily Cunha de Almeida, Caren Nádia Soares de Sousa, Cláudio Felipe Vasconcelos Patrocínio, Danilo dos Santos Diniz, Francisco Maurício Sales Cysne Filho, Luis Rafael Leite Sampaio, Silvânia Maria Mendes Vasconcelos |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Chlorpromazine medicine.medical_treatment Population Motor Activity Pharmacology medicine.disease_cause Hippocampus Antioxidants Lipid peroxidation Random Allocation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Nitriles Animals Medicine Rats Wistar Antipsychotic education Prepulse inhibition education.field_of_study Thioctic Acid Prepulse Inhibition business.industry General Neuroscience Glutathione 030227 psychiatry Disease Models Animal Oxidative Stress Memory Short-Term chemistry Schizophrenia NMDA receptor Drug Therapy Combination Ketamine Lipid Peroxidation business 030217 neurology & neurosurgery Oxidative stress Antipsychotic Agents medicine.drug |
| Zdroj: | Neuroscience. 373:72-81 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2018.01.008 |
| Popis: | Schizophrenia is a chronic mental disorder reported to compromise about 1% of the world's population. Although its pathophysiological process is not completely elucidated, evidence showing the presence of an oxidative imbalance has been increasingly highlighted in the literature. Thus, the use of antioxidant substances may be of importance for schizophrenia treatment. The objective of this study was to evaluate the behavioral and oxidative alterations by the combination of chlorpromazine (CP) and alpha-lipoic acid (ALA), a potent antioxidant, in the ketamine (KET) model of schizophrenia in rats. Male Wistar rats (200–300 g) were treated for 10 days with saline, CP or ALA alone or in combination with CP previous to KET and the behavioral (open field, Y-maze and PPI tests) and oxidative tests were performed on the last day of treatment. The results showed that KET induced hyperlocomotion, impaired working memory and decreased PPI. CP alone or in combination with ALA prevented KET-induced behavioral effects. In addition, the administration of KET decreased GSH and increased nitrite, lipid peroxidation and myeloperoxidase activity. CP alone or combined with ALA prevented the oxidative alterations induced by KET. In conclusion, the treatment with KET in rats induced behavioral impairments accompanied by hippocampal oxidative alterations, possibly related to NMDA receptors hypofunction. Besides that, CP alone or combined with ALA prevented these effects, showing a beneficial activity as antipsychotic agents. |
| Databáze: | OpenAIRE |
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