Spontaneous release of Fc receptor-like material from human lymphoblastoid cell lines
| Autor: | W. P. Zeijlemaker, K. W. Pondman, J. L. Molenaar, M. Van Galen, A.J. Hannema |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Antigen-Antibody Complex
Erythrocytes T-Lymphocytes Lymphocyte Immunology Fc receptor Complement C1 Inactivator Proteins Binding Competitive Immunoglobulin G Cell Line medicine Humans Immunology and Allergy Receptor B-Lymphocytes biology Hemagglutination Cell Membrane Immunoglobulin Fc Fragments DNA Cytotoxicity Tests Immunologic Virology Molecular biology Immune complex medicine.anatomical_structure Immunoglobulin M Cell culture Antibody Formation Hemocyanins biology.protein Binding Sites Antibody |
| Zdroj: | European Journal of Immunology. 7:230-236 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.1830070409 |
| Popis: | In the culture medium of some human lymphoblastoid cell lines material is released with the following properties: (a) hemagglutination reaction of IgG-sensitized erythrocytes; (b) enhancement of precipitation of DNA-anti-DNA complexes; (c) inhibition of binding of C1q to immune complexes; (d) inhibition of immune complex binding to lymphocytes; (e) inhibition of antibody-dependent lymphocytotoxicity. The material is not identical with C1q or rheumatoid factor, it is heat resistant (30 min at 56 degrees C); the molecular weight is about 100 000 daltons and it is capable of inhibiting antibody production in vitro. It is suggested that this material consists of Fc receptors spontaneously shed from lymphocyte membranes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text