Changes in T and B blood lymphocytes after splenectomy
| Autor: | D K Banerjee, R E Millard |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Time Factors Adolescent T-Lymphocytes medicine.medical_treatment Lymphocyte Splenectomy Cell Lymphocyte Activation Pathology and Forensic Medicine Leukocyte Count Humans Medicine Postoperative Period Aged Phytohaemagglutinin B-Lymphocytes biology business.industry Decreased T cells General Medicine Middle Aged Proliferative response In vitro medicine.anatomical_structure Concanavalin A Immunology biology.protein Female business Research Article |
| Zdroj: | Journal of Clinical Pathology. 32:1045-1049 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.32.10.1045 |
| Popis: | The blood lymphocytes of 37 splenectomised patients were analysed by means of T and B lymphocyte surface markers. Sixteen patients had had a splenectomy for non-haematological and 21 for haematological reasons. The results show that 15 had normal numbers of T and B cells; decreased T cells were found in two patients, raised B cells in seven, raised T and B cells in eight, and raised T cells in five patients. Increased numbers of 'null' cells were observed in some patients, especially in those with raised B cells. Follow-up studies indicate that raised levels of T and B cells can be established by one to three months post-splenectomy and may persist, although in some patients the cells fall to normal levels. The lymphocyte proliferative response to phytohaemagglutinin and Concanavalin A in vitro was normal in eight out of nine patients with raised T cells and was depressed in one patient, possibly due to an intrinsic cell defect. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|