Cue-Evoked Dopamine Promotes Conditioned Responding during Learning
| Autor: | Aliza Janse van Rensburg, Cagatay Aydin, Joachim Morrens, José Esquivelzeta Rabell, Sebastian Haesler |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Dopamine Conditioning Classical Presynaptic Terminals Theoretical models Prefrontal Cortex Optogenetics Photometry Mice 03 medical and health sciences 0302 clinical medicine Latent inhibition Reward Salience (neuroscience) medicine Animals Learning Pars Compacta Dopaminergic Neurons General Neuroscience Ventral Tegmental Area Association Learning Classical conditioning Recognition Psychology Associative learning 030104 developmental biology Conditioning Cues Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuron. 106:142-153.e7 |
| ISSN: | 0896-6273 |
| Popis: | Dopamine neurons mediate the association of conditioned stimuli (CS) with reward (unconditioned stimuli, US) by signaling the discrepancy between predicted and actual reward during the US. Some theoretical models suggest that learning is also influenced by the salience or associability of the CS. A hallmark of CS associability models is that they can explain latent inhibition, i.e., the observation that novel CS are more effectively learned than familiar CS. Novel CS are known to activate dopamine neurons, but whether those responses affect associative learning has not been investigated. Here, we used fiber photometry to characterize dopamine responses to inconsequential familiar and novel stimuli. Using bidirectional optogenetic modulation during conditioning, we then show that CS-evoked dopamine promotes conditioned responses. This suggests that Pavlovian conditioning is influenced by CS dopamine, in addition to US reward prediction errors. Accordingly, the absence of dopamine responses to familiar CS might explain their slower learning in latent inhibition. ispartof: Neuron vol:106 issue:1 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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