Psychometric Properties of EQ-5D-3L and EQ-5D-5L in Cognitively Impaired Patients Living with Dementia
| Autor: | Wolfgang Hoffmann, Feng Xie, Bernhard Michalowsky |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Audiology 0302 clinical medicine Quality of life Surveys and Questionnaires Activities of Daily Living Health Status Indicators 030212 general & internal medicine Aged 80 and over validation education.field_of_study 030503 health policy & services General Neuroscience Cognition General Medicine statistics & numerical data [Psychometrics] Psychiatry and Mental health Clinical Psychology Convergent validity patient-reported outcomes Female psychology [Cognitive Dysfunction] Cognitively impaired 0305 other medical science medicine.medical_specialty preference-based measures Psychometrics psychology [Dementia] Population Interviews as Topic 03 medical and health sciences Alzheimer’s diseases EQ-5D psychology [Quality of Life] medicine Humans Dementia Cognitive Dysfunction ddc:610 education business.industry Reproducibility of Results medicine.disease quality of life psychology [Activities of Daily Living] Quality of Life Ceiling effect Geriatrics and Gerontology business dementia |
| Zdroj: | Journal of Alzheimer's disease 83(1), 77-87 (2021). doi:10.3233/JAD-210421 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-210421 |
| Popis: | Background: Assessing health-related quality of life in dementia poses challenges due to patients’ cognitive impairment. It is unknown if the newly introduced EQ-5D five-level version (EQ-5D-5L) is superior to the 3-level version (EQ-5D-3L) in this cognitively impaired population group. Objective: To assess the psychometric properties of the EQ-5D-5L in comparison to the EQ-5D-3L in patients living with dementia (PwD). Methods: The EQ-5D-3L and EQ-5D-5L were assessed via interviews with n = 78 PwD at baseline and three and six months after, resulting in 131 assessments. The EQ-5D-3L and EQ-5D-5L were evaluated in terms of acceptability, agreement, ceiling effects, redistribution properties and inconsistency, informativity as well as convergent and discriminative validity. Results: Mean index scores were higher for the EQ-5D-5L than the EQ-5D-3L (0.70 versus 0.64). Missing values occurred more frequently in the EQ-5D-5L than the EQ-5D-3L (8%versus 3%). Agreement between both measures was acceptable but poor in PwD with moderate to severe cognitive impairment. The index value’s relative ceiling effect decreased from EQ-5D-3L to EQ-5D-5L by 17%. Inconsistency was moderate to high (13%). Absolute and relative informativity increased in the EQ-5D-5L compared to the 3L. The EQ-5D-5L demonstrated a lower discriminative ability and convergent validity, especially in PwD with moderate to severe cognitive deficits. Conclusion: The EQ-5D-5L was not superior as a self-rating instrument due to a lower acceptability and discriminative ability and a high inconsistency, especially in moderate to severe dementia. The EQ-5D-3L had slightly better psychometric properties and should preferably be used as a self-rating instrument in economic evaluations in dementia. |
| Databáze: | OpenAIRE |
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