All-Electronic Quantification of Neuropeptide–Receptor Interaction Using a Bias-Free Functionalized Graphene Microelectrode

Autor:	Ramya Vishnubhotla, Pedro Ducos, Alan T. Johnson, Jinglei Ping, Jeffery G. Saven, Jin Xi, Renyu Liu
Rok vydání:	2018
Předmět:	0301 basic medicine Kinetics Receptors Opioid mu General Physics and Astronomy Neuropeptide Biosensing Techniques 02 engineering and technology Article 03 medical and health sciences medicine Humans Polymethyl Methacrylate General Materials Science Opioid peptide Receptor Chemistry beta-Endorphin General Engineering Electrochemical Techniques Enkephalin Ala(2)-MePhe(4)-Gly(5) 021001 nanoscience & nanotechnology Receptor–ligand kinetics Microelectrode Immobilized Proteins 030104 developmental biology Opioid Peptides Opioid Biophysics Thermodynamics Graphite 0210 nano-technology Microelectrodes Biosensor medicine.drug
Zdroj:	ACS Nano. 12:4218-4223
ISSN:	1936-086X 1936-0851
DOI:	10.1021/acsnano.7b07474
Popis:	Opioid neuropeptides play a significant role in pain perception, appetite regulation, sleep, memory, and learning. Advances in understanding of opioid peptide physiology are held back by the lack of methodologies for real-time quantification of affinities and kinetics of the opioid neuropeptide−receptor interaction at levels typical of endogenous secretion (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ebb2950fe57a53fde4a029bb1dceff https://doi.org/10.1021/acsnano.7b07474 Zobrazit plný text záznamu