Inorganic mesoporous silicas as vehicles of two novel anthracene-based ruthenium metalloarenes
| Autor: | Francisco J. Carmona, Elisa Barea, Carmen R. Maldonado, Sara Rojas |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_element
Apoptosis HL-60 Cells 010402 general chemistry 01 natural sciences Biochemistry Ruthenium Cathepsin B Inorganic Chemistry chemistry.chemical_compound MCM-41 Humans Organic chemistry Anthracenes chemistry.chemical_classification Drug Carriers Anthracene Cytotoxins 010405 organic chemistry Silicon Dioxide Combinatorial chemistry Fluorescence 0104 chemical sciences Amino acid chemistry Mesoporous material Porosity Cysteine |
| Zdroj: | Journal of Inorganic Biochemistry. 166:87-93 |
| ISSN: | 0162-0134 |
| Popis: | Two novel anthracene-based half-sandwich organometallic Ru(II) compounds, namely, [Ru(p-cymene)(L1)Cl2] (1) and [Ru(p-cymene)(L2)Cl2] (2) (L1=1-(anthracen-9-yl)-N-(pyridin-3-ylmethyl)methanamine; L2=1-(anthracen-9-yl)-N-(pyridin-4-ylmethyl)methanamine) have been synthesized and characterized. We demonstrate that the fluorescence properties of these complexes are highly affected by the linking position of the anthracene unit, as only 2 shows fluorescence emission in the blue region. Regarding their biological activity, both ruthenium metallodrugs show interaction with different biological targets such as S-donor amino acids (cysteine) and proteases (cysteine cathepsin B). Moreover, 1 and 2 show in vitro cytotoxicity against HL-60 cancer cell line (IC50=84.5 and 87.0μM for 1 and 2, respectively), with cell death occurring via apoptosis. Further studies have shown that diffusion into cells is the main mechanism of metallodrug uptake. Finally, as a proof of concept, these ruthenium complexes have been successfully encapsulated into MCM-41 and SBA-15 mesoporous silicas using two different incorporation strategies (impregnation and grinding). |
| Databáze: | OpenAIRE |
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