Comparison of Antitumor Effects of Combined and Separate Treatment with NO Synthase Inhibitor T1023 and PDK1 Inhibitor Dichloroacetate
| Autor: | T S Podosinnikova, Makarchuk Vm, Shevchenko Li, A.S. Samsonova, Filimonova Mv, A. S. Filimonov |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
NOS inhibitor Antineoplastic Agents Adaptive potential Pharmacology General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences 0302 clinical medicine Cell Line Tumor No synthase medicine Animals Cytotoxic T cell Neoplasm Tumor growth Carcinoma Ehrlich Tumor Dichloroacetic Acid Hydrobromide Chemistry Thiourea Pyruvate Dehydrogenase Acetyl-Transferring Kinase General Medicine medicine.disease 030104 developmental biology Female Nitric Oxide Synthase 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 168:92-94 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Combined chronic treatment of Ehrlich solid carcinoma (EC) with an NOS inhibitor 1-isobutanoyl-2-isopropylisothiourea hydrobromide (T1023) and a PDK1 inhibitor dichloroacetate was accompanied by statistically significant synergetic antitumor effects manifested in a significant and stable suppression of neoplasm growth (by 55-65%). Separate treatment with T1023 and dichloroacetate induced moderate short-term inhibition of tumor growth (by 30-35%) followed by weakening of tumor sensitivity to these substances. These results attest to synergetic antitumor effects NOS inhibitor T1023 and PDK1 inhibitor dichloroacetate producing antiangiogenic and hypoxia-targeted cytotoxic effects, during their combined administration, which allows overcoming the adaptive potential of the tumors. |
| Databáze: | OpenAIRE |
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