A comparative diffusion tensor imaging study of patients with and without treatment-resistant schizophrenia
| Autor: | Sandeep Grover, Chirag Kamal Ahuja, Niranjan Khandelwal, Ajit Avasthi, Anisha Aggarwal, Subho Chakrabarti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
endocrine system
animal structures medicine.diagnostic_test business.industry Global Assessment of Functioning Magnetic resonance imaging medicine.disease behavioral disciplines and activities schizophrenia treatment resistance Psychiatry and Mental health Diffusion tensor imaging nervous system Schizophrenia Fractional anisotropy Brief Psychiatric Rating Scale medicine Clinical Global Impression Effective diffusion coefficient Original Article Nuclear medicine business hormones hormone substitutes and hormone antagonists Diffusion MRI |
| Zdroj: | Indian Journal of Psychiatry |
| ISSN: | 1998-3794 0019-5545 |
| Popis: | Aim: The aim was to study the brain connectivity using diffusion tensor imaging (DTI) among patients with treatment-resistant schizophrenia (TRS) and compare the same with a group of patients without TRS. Methods: Twenty-three patients with TRS and 15 patients without TRS underwent DTI using a 3T magnetic resonance imaging machine. DTI data were processed with the calculation of fractional anisotropy (FA) and apparent diffusion coefficient. Patients were also assessed on Brief Psychiatric Rating Scale, Positive and Negative Symptom Scale, Global Assessment of Functioning Scale, and Clinical Global Impression severity scale. Results: Patients with TRS and non-TRS differed significantly in the FA values in the region of right superior longitudinal fasciculus and right uncinate fasciculus, with more integrity of tracts in the non-TRS group. However, these differences disappeared when Bonferroni correction was used for multiple comparisons. Conclusion: The present study suggests lack of significant difference in DTI findings between patients with TRS and non-TRS. |
| Databáze: | OpenAIRE |
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