Comparative study on the changes of bacterial species and severity of antimicrobial resistance during 13 years
| Autor: | Xinglong He, Xin Yuan, Kairui Zhou, Huili Zhang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Bacilli
Imipenem medicine.drug_class Gram-positive bacteria Science Antibiotics Drug resistance Microbial Sensitivity Tests Pathology and Laboratory Medicine Tazobactam Microbiology Klebsiella Pneumoniae Species Specificity Microbial Control Klebsiella Pseudomonas Drug Resistance Bacterial medicine Medicine and Health Sciences Microbial Pathogens Gram Negative Bacteria Pharmacology Multidisciplinary biology Bacteria Antimicrobials Gram Positive Bacteria Organisms Biology and Life Sciences Drugs Pseudomonas Aeruginosa Bacteriology Sulbactam biology.organism_classification Anti-Bacterial Agents Bacterial Pathogens Cefoperazone Medical Microbiology Antibiotic Resistance Medicine Antibacterials Antimicrobial Resistance Pathogens medicine.drug Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 8, p e0256375 (2021) |
| ISSN: | 1932-6203 |
| Popis: | Background With the widespread use of broad-spectrum antibiotics, the problem of bacterial resistance has become a global crisis. To monitor bacterial resistance in our hospital, the distribution of specimens, the detection of pathogens and their drug resistance from July 2005 to June 2007 (13 years ago) and July 2018 to June 2020 were compared and analyzed. Methods Ordinary specimens (such as sputum, urine, feces, and secretion) were inoculated in blood AGAR media, MacConkey medium, chocolate medium, double SS medium and selective culture medium. Blood, cerebrospinal fluid, pleural effusion, joint cavity effusion and other sterile body fluid samples were inoculated in aerobic and anaerobic blood culture flasks. Automatic microbial identification, drug sensitivity analysis and mass spectrometry analysis were used to determine their drug sensitivity. Results Compared with the results obtained 13 years ago, the number of specimens submitted for inspection in the past two years has increased significantly, exhibiting a growth rate of 283%. The changes in the pathogen species were obvious. Gram-positive cocci were the dominant bacteria 13 years ago, and Gram-negative bacilli were the dominant bacteria in the past two years. In addition, the resistance of several major Gram-negative bacilli to piperacillin/tazobactam, cefoperazone/sulbactam, meropenem and imipenem all showed an increasing trend. Conclusion The variety of pathogenic bacteria in our hospital has changed significantly in the past two years compared with that 13 years ago, and the clinical isolates of Gram-negative bacilli have increased significantly compared with Gram-positive cocci. In the clinical treatment of anti-infective diseases, antimicrobial agents should be selected according to the bacterial distribution characteristics and drug resistance in each hospital. |
| Databáze: | OpenAIRE |
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