Synthesis, structure, DNA binding and anticancer activity of a new tetranuclear Pb(II) complex constructed by 8-hydroxyquinolinate and 4-nitrobenzoate ligands
| Autor: | Wei-Min Xia, Li-Ping Zhang, Lu-Lu Lv, Yuan-Zheng Cheng, Xue-Dong Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
crystal structure
010405 organic chemistry Chemistry 8-hydroxyquinolinate Metals and Alloys General Chemistry Crystal structure dna-binding 010402 general chemistry Condensed Matter Physics 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound pb(ii) anticancer activity 4-nitrobenzoate Materials Chemistry QD1-999 DNA |
| Zdroj: | Main Group Metal Chemistry, Vol 42, Iss 1, Pp 60-66 (2019) |
| ISSN: | 2191-0219 |
| DOI: | 10.1515/mgmc-2019-0006 |
| Popis: | A new Pb(II) complex, [Pb(8-OQ)(4-NB)], where 8-OQ = 8-hydroxyquinolinate, 4-NB = 4-nitrobenzoate, has been synthesized and characterized by elemental analysis, IR spectroscopy, and X-ray single-crystal diffraction. The single crystal X-ray analysis reveals that the complex possesses a tetranuclear Pb4O4 cubane structure. The Pb(II) atom is coordinated by three triply bridging phenolic hydroxyl O atoms of 8-OQ ligands, then the tetranuclear Pb system is formed resulting in a tetrahedral cage. The interaction of complex with HS-DNA in Tris buffer was studied by UV−vis absorption spectrum and fluorescence ethidium bromide displacement experiment with an intrinsic binding constant of 1.52×104 M-1 and a linear Stern–Volmer quenching constant of 6.77×103 M-1. Anticancer activity against MCF-7, HepG-2 and A549 cell lines of complex was also determined by the MTT-based assay. The results showed the complex can inhibit proliferation of these three kinds of tumor cells and is less cytotoxic than cisplatin. |
| Databáze: | OpenAIRE |
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